November 30, 2023

Dietary influences on colorectal cancer

The Chinese authors of this study deserve credit for a very careful and thorough study. In the end, however the results are no different from less well-controlled previous studies: Weak effects. All the relationships were marginal, and weak effects tend not to replicate well.

So it is extremely UNlikely that alcohol and white bread will give you colorectal cancer. A bread enthusiast living to be 100 could be expected


Diet-Wide Association, Genetic Susceptibility and Colorectal Cancer Risk: A Prospective Cohort Study

Dongqing Jin et al.

Abstract

Background: Both genetic and dietary factors play significant roles in the etiology of colorectal cancer (CRC). To evaluate the relationship between certain food exposures and the risk of CRC, we carried out a large-scale association analysis in the UK Biobank. Methods: The associations of 139 foods and nutrients’ intake with CRC risk were assessed among 118,210 participants. A polygenic risk score (PRS) of CRC was created to explore any interaction between dietary factors and genetic susceptibility in CRC risk. The hazard ratio (HR) and 95% confidence interval (CI) of CRC risk linked to dietary variables and PRS were estimated using Cox regression models. Multiple comparisons were corrected using the error discovery rate (FDR).

Results: During a mean follow-up of 12.8 years, 1466 incidents of CRC were identified. In the UK Biobank, alcohol and white bread were associated with increased CRC risk, and their HRs were 1.08 (95% CI: 1.03–1.14; FDRP = 0.028) and 1.10 (95% CI: 1.05–1.16; FDRP = 0.003), whereas dietary fiber, calcium, magnesium, phosphorus, and manganese intakes were inversely associated. We found no evidence of any PRS–nutrient interaction relationship in relation to CRC risk. Conclusions: Our results show that higher intakes of alcohol and white bread are associated with increased CRC risk, whilst dietary fiber, calcium, magnesium, phosphorus, and manganese are inversely associated.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674290/

https://www.news.com.au/lifestyle/health/diet/new-study-reveals-very-bad-news-for-bread-lovers/news-story/fe3676a56a2b016b27f075d11eec4651





This note originated as a blog post. For more blog postings from me, see
DISSECTING LEFTISM,
TONGUE-TIED,
EDUCATION WATCH INTERNATIONAL,
GREENIE WATCH,
POLITICAL CORRECTNESS WATCH,
AUSTRALIAN POLITICS and
IMMIGRATION WATCH.

I update those frequently.



Much less often, I update Paralipomena , A Coral reef compendium and an IQ compendium. I also put up occasional updates on my Personal blog and most days I gather together my most substantial current writings on THE PSYCHOLOGIST.



Email me here (Hotmail address). My Home Pages are here (Academic) or here (Personal). My annual picture page is here; Home page supplement; Menu of my longer writings; Menu of my short notes